Placent Aging
Aging process involves both fetal and maternal components.
1. Villi changes
Aggregation of synctium in small area on sides of villus.
a. Decreasing thickness of syncytium and appreances of syncytial knots.
b. Disappearance of trophoblast cells partial
c. Decrease in stromal tissue including hofbauer cells (fetal macrophages).
d. Destruction of some vessel and dilatation of capillaries.
e. Thickening of basement layer of fetal endothelium and cytotrophoblast.
f. Deposition of fibrin on the surface of villi.
2. Decidual changes
Fibrinoid degeneration (fibrinoid necrosis) called nitabuch layer.
Limits the further invasion of decidua by trophoblast.
This membrane is absent in placenta accreta.
Placenta accreta; placenta grows too deeply into uterine wall.
3. Intervillous Space
White infarcts
Calcification or even cyst formation near placental degeneration margin.
Rohr's stria (intervillous fibrin deposition.
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