Oxygen Transportation
Oxygen transport dissolve.easily in water so only about 3% in dissolve state in blood plasma. Rest of about 97% of oxygen is transported in combination with hemoglobin in RBC.
Oxygen + Hemoglobin = Oxyheamoglobin
O2+Hb-HbO2
The binding is reversible.
Haemoglobin and Oxygen partial pressure(PO2)
The most important factor that.determines the amount of oxygen combining with haemoglobin is PO2. Higher the PO2, more O2 will combine with haemoglobin. and should less concentration of CO2 because CO2 is more affinity to bound haemoglobin.
Each haemoglobin molecule to bind 4 oxygen molecules.
Hb+4O2- Hb(O2)4
Important Condition for the.Oxygen-
Haemoglobin complex to be form-
1. PO2 must be higher
2. PCO2 must be low
3. pH must be high
4. Temperature must be low
5. BPG level must be low
(Found in RBC)
In pulmonary capillaries where PO2 is high (104mmHg) O2 binds to hemoglobin and in tissue spaces where PO2 is lower, 40mmHg O2 is released from haemoglobin for diffusion into tissue cells.
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