Vitamin B7
Called Biotin/Vitamin H/ coenzyme R/ anti egg white injury factor.
Biotin is sulphur containing vitamins, Imidazole ring.
Also synthesized by intestinal flora, and also found in diet.
Biotin have 2 forms;
1. Alpha biotin (in eggyolk)
2. Beta biotin (in liver)
Needed for glucose and fatty acid formation.
Recommended daily allowance
0-6 months infants; 5mcg/ day (μg/day).
Function
1. Help to maintain skin and nervous system.
2. Essential for synthesis of malonyl CoA from Acetyl CoA and oxaloacetic acid from pyruvic acid.
3. Essential for fatty acid synthesis.
Clinical manifestation of deficiency
1. Fine scaly skin peeling without pruritis.
2. Muscle pain and hyperesthesia (increase sensitivity to stimulation).
3. Anorexia with nausea
4. Extreme lassitude (physical or mental tiredness)
5. Mild depression
Management
1. Oral dose
2. Injection dose
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