life cycle of leishmania

Life cycle of Leishmania

Leishmania parasite passes it's life cycle, in two host; 

1. Man and animal

2. Sand fly (insect vector)

In human, it become adult (round or with flagella) and called rhizoblast, where it multiply sexually.

But in sand fly parasite multiple asexually binary fission but don't form cyst.

Leishmania parasite has two stages in it's life cycle.

1. Amastigote form

Seen in human and animals.

2. Promastigote form

Seen in sandfly (insect vector).

Inflected sand fly when bite human skin, it inject flagella promastigotes in skin.

Promastigote form loose their flagella called amastigote form in humans.

Amastigotes enter into reticuloendothelial system of human involving; spleen, liver, bone marrow.

Amastigotes multiply in reticuloendothelial system of humans.

When sand fly bites infected person, acquire amastigotes.

Amastigotes divide in sand fly gut and produce promastigotes.

Life cycle of parasite repeated.

1. Infected sandfly bite human skin, it inject flagella promastigotes in skin.

2. Promastigotes form changes into amastigotes in humans.

3. In human, Amastigotes enter into reticuloendothelial system of human; spleen, liver, and bone marrow.

4. When amastigotes multiply in reticuloendothelial system of human; spleen, liver, bone marrow.

5. Sand fly bites an Infected person and acquire amastigotes.

6  Amastigotes divide in sand flys gut and produce promastigotes.