Neutrophil

 

Neutrophils

Neutrophils, neutrophils are most common type of leukocytes. These are phagocytes that engulf and destroy microorganisms and other foreign materials.

Size; 12-15micrometer in diameter

Nuclei of neutrophils have 2-6 lobes, connected very thin strands.

Neutrophils have cytoplasmic granules, granules inside the cytoplasm are pockets of enzymes. These enzymes contribute to the neutrophils vital role in the defense against invading microorganism.

In the course of phagocyyosis the neutrophils may also be destroyed and their granules are depleted.

Dead microorganism, dead tissue and neutrophils make up the thick, whitish fluid called pus.

Function of Neutrophils

1. Innate immune system

2. Protect against foreign material to entry

3. Chemotaxis, specific chemical released at site of infection or tissue injury attract neutrophils

5. Engulf and destroy bacteria and other pathogen

6. Diapedesis

7. Capable of amoeboid movement

8. Phagocytosis

Neutrophils increases in number in following condition-

It increases in severe exercise and late stages of pregnancy.

In other condition such as-

Microbial infection

Where there is tissue damage example, coronary thrombosis, burns.

Metabolic condition example, diabetic ketoacidosis.

Leukemia

Heavy smoking

Use of oral contraceptives