Adrenocorticotropic hormone (ACTH)
Corticotropin releasing hormone (CRH) from Hypothalamus promotes the synthesis and release of ACTH (adrenocorticotropic hormone) by anterior pituitary.
Function
ACTH stimulates adrenal cortex to release corticosteroid hormones, most importantly glucocorticoids that help body to resist stressors.
ACTH plays a central role in body's response to stress.
Regulation of Secretion
ACTH release stimulated by hypothalamic CRH.
ACTH level are highest at morning.
Secretion is also regulated by Negative feed back mechanism.
Raising levels of glucocorticoids feedback and block secretion of CRH and ACTH release.
Other factor that stimulate secretion include hypoglycemia, excercise and stressors of all type such as emotional status and fever.
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