Viral inclusion bodies
Based on their location either at nucleus or cytoplasm or at both cell organelles;
1. Intracytoplasmic
Negri bodies in rabies
Bollinger bodies and borrel bodies in fowl pox.
Paschen bodies in variola (small pox)
Handerson-Patterson bodies in molluscum contagiosum.
Eosinophilic inclusion bodies inclusion body disease.
2. Intranuclear
a. Acidophilic (growing best at acidic conditions)
Cowdry type A in varicella zoster virus.
Herpes simplex virus
Yellow fever virus
Cowdry type B poliovirus
b. Basophilic
Cowdry type B in adenovirus
Owl's eye appearance in cytomegalovirus
Inclusion bodies are abonormal structure with distinct size and shape and usually observed in;
Nerve
Epithelial
Endothelial cells
They have characteristics staining property and are typically composed of proteins.
Inclusion bodies in;
Cystic leasion
Blood dyscrasias
Fungal infection
Viral infected cells
Bacterial infection
Autoimmune disease
Neoplasms
Key point on Inclusion Bodies
1. Inclusion bodies are cytoplasmic or nuclear aggregates stainable substance.
2. When gene from one organism are expressed in some other organism, protein synthesis form inclusion bodies.
3. They are generally acidophilic
4. They are made of virus antigen present at the site of virus synthesis.
5. They are seen pink structure when stained with gypsum or methylene blue dye.
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