About 85%'of people have Rh antigen, they are rehesus positive (Rh+ve). Remaining 5% have no Rhesus antigen. They are rhesus negative, or (Rh-ve).
If an Rh-ve person recieves an Rh+ve blood transfusion, immune system starts to make anti Rh antibodies that wil remain in blood.
If a second transfusion of Rh+ve blood is given later, previously formed Rh antibodies will cause agglutination and hemolysis of RBCs blood and severe reaction.
Rh-ve pregnancy is a condition that occurs when mothers's blood group is Rh-ve and baby's blood group is Rh+ve
Baby's blood enters mothers blood circulation sometimes during pregnancy and/ or labour and child-birth.
Mothers blood cells recognize fetal Rh+ve red blood cell as foreign and produce anti Rh antibodies to destroy the cells.
Rh antibodies refers fetal circulation with mothers blood and destroy fetal red blood cells causing hemolytic
disease of the newborn leading to anemia and jaundice in the body.
If a unit of incompatible blood is transfused between a donor and recipient, a severe acute hemolytic reaction with hemolysis (RBC destruction), renal failure and shock occured and death is possibly.
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