Tumor suppressor Gene or anti-oncogene
TSG genes that slow down cell division, rapair DNA mistakes or tell cells when to die (apoptosis or programmed cell).
When tumor suppressor gene don't work properly, cell can grow out of control, can lead to cancer.
For example; BRCA 1/BRCA 2 genes; breast cancer
TP53; regulate cell division
P53; DNA repair/Apoptosis
AP- colon cancer
MAD2; colon cancer
Rb; Retinoblastoma
Function of Tumor suppressor gene
1.Cell cycle regulation gene
2. Checkpoint control gene
3. Apoptosis related gene
4. DNA repair protein
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